Table 1.
Biological functions of various collagen fragments
| Collagens | Fragments | Biological functions |
|---|---|---|
| Col I | Trimer carboxyl propeptide |
Chemotactic for endothelial cells (Palmieri et al., 2000) |
| Various fragments | Chemotactic for dermal fibroblasts and peripheral monocytes (Albini and Adelmann-Grill, 1985; Malone et al., 1991) |
|
| Col II | Various fragments | Inhibit collagen synthesis and MMP secretion by chondrocytes (Jennings et al., 2001) |
| C-propeptide or chondrocalcin |
Cartilage calcification (Alini et al., 1992; Van der Rest et al., 1986) | |
| Col IV | NC1 and 7S domains | Inhibit morphogenesis in Hydra vulgaris (Sarras et al., 1993) |
| NC1 domain | Promote axonal growth (Lein et al., 1991) | |
| α1 NC1, arresten | Anti-angiogenic (Colorado et al., 2000) | |
| α2 NC1, canstatin | Anti-angiogenic (Kamphaus et al., 2000; Petitclerc et al., 2000) | |
| α3 NC1, tumstatin | Anti-angiogenic (Maeshima et al., 2000; Petitclerc et al., 2000) | |
| α6 NC1 | Anti-angiogenic (Petitclerc et al., 2000) | |
| Col VIII | NC1 domain vastatin | Angiogenic (Xu et al., 2001) |
| Col XIV | N-terminal fragment | Chemotactic for neutrophils (Nakagawa et al., 1999) |
| Col XV | NC1 | Anti-angiogenic (Sasaki et al., 2000) |
| Restin | Anti-angiogenic (Ramchandran et al., 1999; Sasaki et al., 2000) | |
| Col XVIII | NC1 | Induce migration of neural and non-neural cells in C. elegans (Ackley et al., 2001) |
| Endostatin | Anti-angiogenic (O’Reilly et al., 1997) | |
| Inhibit branching morphogenesis (Karihaloo et al., 2001) |