. 2009 Jul 22;284(43):29893–29904. doi: 10.1074/jbc.M109.028449

TABLE 2.

Echocardiography parameters in AB Timp3^−/− mice treated with 1D11, TGFβ−blocking antibody

AB, aortic banding; HR (beats/min), heart rate; LVEDD, LVESD (mm), left ventricular end diastolic and systolic dimension, respectively; LVEDI (mm/mg), left ventricular end diastolic index (= LVEDD/body weight); FS, fractional shortening (= LVEDD − LVESD)/LVEDD × 100%; VCF_c (circumference/s), velocity of circumferential shortening corrected for HR = FS/ET_c; PAV_c (cm/s), peak aortic velocity corrected for HR.

	3 weeks post-AB			6 weeks post-AB
	WT	Timp3^−/− + vehicle	Timp3^−/− + 1D11	WT	Timp3^−/− + vehicle	Timp3^−/− + 1D11
n	8	8	8	8	8	8
HR (beats/min)	535 ± 7	544 ± 9	554 ± 10	542 ± 9	537 ± 15	551 ± 12
PWT (mm)	0.84 ± 0.05	0.82 ± 0.03	0.63 ± 0.04^a	0.8 ± 0.04	0.89 ± 0.05	0.75 ± 0.03^a
LVEDD (mm)	3.77 ± 0.1^a	4.8 ± 0.1	4.08 ± 0.09^a	4.35 ± 0.08^a	5.41 ± 0.12	4.74 ± 0.05
LVESD (mm)	1.78 ± 0.1^a	3.56 ± 0.2	2.3 ± 0.1^a	2.6 ± 0.09^a	4.35 ± 0.24	3.015 ± 0.06^a
FS (%)	52.8 ± 1.3^a	25.8 ± 2.2	42.9 ± 1.2^a	40.2 ± 1.7^a	19.6 ± 2.2	36.2 ± 0.72^a
VCF_c (circumference/s)	9.78 ± 0.3^a	4.62 ± 0.5	8.71 ± 0.4^a	7.83 ± 0.27^a	3.92 ± 0.3	7.12 ± 0.32^a
PAV_c (cm/s)	95.7 ± 2.3^a	70.9 ± 2.1	99.1 ± 1.2^a	84.9 ± 2.4^a	66.3 ± 3.1	97.5 ± 1.80^a
E/A_c ratio	2.52 ± 0.31^a	1.78 ± 0.33	2.45 ± 0.27^a	2.13 ± 0.13^a	1.43 ± 0.33	2.08 ± 0.15^a
EDR (cm/s²)	2.68 ± 0.23^a	2.01 ± 0.17	2.59 ± 0.21^a	2.44 ± 0.11^a	1.98 ± 0.09	2.29 ± 0.20^a

p < 0.05 compared with Timp3^−/−-AB.