Table 1.
GABAergic and subplate developmental neural events are statistically “translated” between rats and mice.
| Translating mouse to rat/rat to mouse predicted by model in white type | Mouse PC day | Rat PC day | Lower CI log | Upper CI log |
|---|---|---|---|---|
| GABAergic cells first generated | 9.7 | 117 | 2.1 | 2.4 |
| MGE begins generating burst spiking interneurons | 9.51,5 | 10.8 | 2.2 | 2.5 |
| Tangential migration begins from MGE to subplate | 11.511 | 13 | 2.4 | 2.7 |
| “Handshake” in ganglionic eminence (striate primordium) | 138 | 14.7 | 2.6 | 2.8 |
| GAD positive cells in subplate and layer I | 13.2 | 157 | 2.5 | 2.7 |
| CGE begins generating regular spiking interneurons (adapting) | 13.55 | 15.2 | 2.6 | 2.9 |
| MGE begins generating fast spiking interneurons (PV) | 13.56 | 15.3 | 2.6 | 2.9 |
| LGE generates GABA cells for proliferative zone – start | 141 | 15.9 | 2.6 | 2.9 |
| GABAir cells in all cortical laminae formed at this point – start | 14.1 | 1612 | 2.5 | 2.8 |
| GABAir cells in all cortical laminae formed at this point – end | 15 | 1712 | 2.6 | 2.8 |
| GABA positive cells decrease in lower intermediate zone | 15 | 177 | 2.6 | 2.8 |
| GABA positive cells conspicuous in white matter | 15.9 | 187 | 2.6 | 2.9 |
| LGE generates cortical cells GABA – destined for proliferative zone – end | 161 | 18.1 | 2.8 | 3.0 |
| Robust migration from MGE to cortex ends | 161 | 18.1 | 2.8 | 3.0 |
| Subplate cells contain GABA in adult–like fashion (17%) – start | 168 | 18.1 | 2.8 | 3.0 |
| Peak levels of GABA–induced migration | 16.3 | 18.52,3 | 2.7 | 2.9 |
| GABAir cells no longer in lower intermediate zone | 16.8 | 1912 | 2.7 | 2.9 |
| GABA influences neurite outgrowth | 16.8 | 1910 | 2.7 | 2.9 |
| Subplate cells contain GABA in adult–like fashion (17%) – end | 178 | 19.2 | 2.8 | 3.1 |
| Intra GABA subplate communication – start | 18.9 | 21.59 | 2.8 | 3.1 |
| GABA switches from excitatory to inhibitory – start | 20.8 | 23.54 | 2.9 | 3.2 |
| Intra GABA subplate communication – end | 21.6 | 24.59 | 2.9 | 3.2 |
| GABA switches from excitatory to inhibitory – end* | 24.3 | 28.54 |
*Base event; translation generated at www.translatingtime.net.
References: 1 (Anderson et al., 2001), 2 (Behar et al., 1996), 3 (Behar et al., 1998), 4 (Ben-Ari et al., 1997), 5 (Butt et al., 2007), 6 (Butt et al., 2005), 7 (DeDiego et al., 1994), 8 (Del Rio et al., 2000), 9 (Hanganu et al., 2002), 10 (Maric et al., 2001), 11 (Marin and Rubenstein, 2001), 12 (Van Eden et al., 1989).
Abbreviations: MGE (medial ganglionic eminence); GABA (γ-aminobutyric acid); SOM (somatostatin); CR (calretinin); VIP (vasointestinal polypeptide); PV (parvalbumin); LGE (lateral ganglionic eminence); GAD (glutamic acid decarboxylase); GABAir (γ-aminobutyric acid immunoreactive).