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. 2009 Nov 26;5(11):e1000673. doi: 10.1371/journal.ppat.1000673

Table 1. Incubation periods for prion-infected MDR0/0, FVB and CD1 mice orally treated with 40 mg/kg/day of quinacrine.

Mouse line Treatment initiated (dpi) Treatment duration (d) Incubation period (days±SEM)
MDR0/0 30 60 135±4
30 30 143±1 *
60 30 128±3
60 20 141±2 *
60 10 141±2 *
60 until death 115±2
0 until death 115±4
untreated - 124±3
FVB 60 30 128±1 *
60 until death 118±2
untreated - 121±2
CD1 105 until death 121±2
95 30 129±5
95 until death 129±3
80 30 116±4
80 until death 121±2
70 30 145±5 *
70 60 131±5
70 until death 121±2
untreated - 127±2

*: Statistically significant (P<0.01) prolongation of the incubation period compared to untreated controls. For all experiments, n = 9 mice.