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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Curr Opin Cell Biol. 2009 Jul 14;21(5):701–707. doi: 10.1016/j.ceb.2009.06.005

Figure 2.

Figure 2

Mechanisms of JAM-A mediated leukocyte transmigration. Potential mechanisms for the effects of JAM-A (blue) on leukocyte (yellow) migration include: A) adhesion receptor-ligand interactions, B) alterations in endothelial/epithelial intracellular signaling due to trans-interactions with leukocytes, C) alterations in JAM-A leukocyte signaling and cell polarity through Par3/Par6/aPKC (green), and D) interference with JAM-A signaling by soluble JAM-A (sJAM-A, in blue). Not shown is intracellular leukocyte signaling due to trans-interactions as highlighted in 2B for endothelial/epithelial cells.