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. Author manuscript; available in PMC: 2010 Aug 15.
Published in final edited form as: J Immunol. 2009 Jul 20;183(4):2312–2320. doi: 10.4049/jimmunol.0900185

Figure 8. Lack of a role of B-cell derived IL-10 in restraining immune activation after challenge with LPS.

Figure 8

Wild type (closed black square), IL-10-/- (open square), Il10flox/flox (filled diamond) and Il10flox/floxCD19-Cre (open diamond) mice were challenged i.p. with 20 mg/kg E. coli LPS. (a) Endotoxicity score (comprised of lethargy, piloerection, ocular discharge and diarrhea (23)) and (b) Survival. Data represent the mean score (± SEM) (a) and mean percentage (b) in 7 WT, 12 IL-10-/-, 14 Il10flox/flox and 15 Il10flox/floxCD19-Cre mice. Due to the early mortality in IL-10-/- mice, endotoxicity scores are only available for the 6 h time point with these mice.