Table 2.
Modeling in the GDT with Environmental and Genetic Factors
| Adjusted |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chr | SNP | MAF | Position (bp) | Gene | Ref | None: 1.008 GC | Sex: 1.010 GC | Sex, INS: 1.002 GC | Sex, INS, IBD: 0.987 GC |
| 11 | rs1004446 | 0.310 | 2126719 | INS | 35 | 3.6 × 10−10 | 3.1 × 10−10 | N/A | N/A |
| 21 | rs876498 | 0.453 | 42714896 | UBASH3A | 33 | 5.9 × 10−6 | 5.3 × 10−6 | 5.2 × 10−6 | 4.3 × 10−6 |
| 12 | rs737280 | 0.265 | 110679359 | SH2B3 | 36 | 1.6 × 10−5 | 1.5 × 10−5 | 1.1 × 10−5 | 1.1 × 10−5 |
| 22 | rs714027 | 0.441 | 28902325 | (multiple) | 37 | 7.5 × 10−5 | 7.9 × 10−5 | 7.5 × 10−5 | 7.1 × 10−5 |
| 16 | rs887864 | 0.327 | 11066386 | CLEC16A | 35 | 7.9 × 10−5 | 1.1 × 10−4 | 5.7 × 10−5 | 5.4 × 10−5 |
| 6 | rs169679 | 0.453 | 28964551 | HLA | 38 | 1.2 × 10−4 | 1.1 × 10−4 | ||
| 7 | rs1543851 | 0.374 | 64250422 | 1.3 × 10−4 | 1.5 × 10−4 | 1.1 × 10−4 | 1.2 × 10−4 | ||
| 10 | rs942434 | 0.368 | 7277013 | 1.7 × 10−4 | |||||
| 6 | rs11908 | 0.405 | 33052724 | HLA | 38 | 2.0 × 10−4 | |||
Only associations with a p value ≤ 0.0002 are listed, and associations that have been reported by other studies are indicated in bold. Genomic control numbers are indicated below each model. Abbreviations are as follows: Chr, chromosome; MAF, major allele frequency; Ref, reference; GC, genomic control; IBD, identity by descent.