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. 2009 Sep 4;1(9):83. doi: 10.1186/gm83

Table 3.

Genes differentially expressed in common among colon cancer cell lines resistant to MTX

GenBank ID Gene name Description Ratio HT29 Ratio Caco-2
AI144299 DHFR Dihydrofolate reductase 7.25 46.35
BC005238 FXYD3 FXYD domain containing ion transport regulator 3 7.24 2.20
BC003584 DHFR Dihydrofolate reductase 6.96 50.23
BC000192 DHFR Dihydrofolate reductase 6.89 38.31
NM_002380 MATN2 Matrilin 2 6.62 4.70
BU078629 ZFYVE16 Zinc finger, FYVE domain containing 16 6.06 22.73
NM_001975 ENO2 Enolase 2 (gamma, neuronal) 5.98 2.04
NM_017954 CADPS2 Ca2+-dependent activator protein for secretion 2 5.60 2.27
AI991103 AXIIR Similar to annexin II receptor 5.14 2.03
NM_000791 DHFR Dihydrofolate reductase 4.71 21.17
U05598 AKR1C2 Aldo-keto reductase family 1, member C2 4.63 10.15
M33376 AKR1C2 Aldo-keto reductase family 1, member C2 4.41 8.89
NM_012242 DKK1 Dickkopf homolog 1 4.25 2.56
NM_014867 KBTBD11 Kelch repeat and BTB (POZ) domain containing 11 4.22 2.14
AB037848 KIAA1427 Synaptotagmin XIII 4.13 9.56
NM_014733 ZFYVE16 Zinc finger, FYVE domain containing 16 4.11 15.6
NM_001353 AKR1C1 Aldo-keto reductase family 1, member C1 3.94 8.87
NM_002439 MSH3 MutS homolog 3 3.87 4.00
S68290 AKR1C1 Aldo-keto reductase family 1, member C1 3.66 9.45
J04810 MSH3 MutS homolog 3 3.27 8.23
NM_000691 ALDH3A1 Aldehyde dehydrogenase 3 family, member A1 2.86 3.81
AI718385 SLC26A2 Solute carrier family 26 member 2 2.76 2.02
NM_003069 SMARCA1 SWI/SNF related, regulator of chromatin a1 2.60 2.49
AB029026 TACC1 Transforming, acidic coiled-coil containing protein 1 2.35 3.89
NM_006283 TACC1 Transforming, acidic coiled-coil containing protein 1 2.31 3.26
AF188298 DAB2 Disabled homolog 2 2.29 2.11
NM_020299 AKR1B10 Aldo-keto reductase family 1, member B10 2.26 22.95
BC006471 MLLT11 Myeloid/lymphoid or mixed-lineage leukemia 2.18 2.60
W93554 SH3PXD2A SH3 and PX domains 2A 2.14 3.45
NM_014778 NUPL1 Nucleoporin like 1 0.46 0.43
NM_006033 LIPG Lipase, endothelial 0.40 0.42
NM_012338 TM4SF12 Transmembrane 4 superfamily member 12 0.39 0.38
NM_007150 ZNF185 Zinc finger protein 185 (LIM domain) 0.38 0.42
AB014605 MAGI2 Membrane associated guanylate kinase 0.38 0.30
AB033831 SCDGF Platelet derived growth factor C 0.35 0.35
NM_021021 SNTB1 Syntrophin, beta 1 0.35 0.23
NM_021822 APOBEC3G Apolipoprotein B, catalytic polypeptide-like 3G 0.30 0.08
AB039791 ARP11 Actin-related protein Arp11 0.29 0.46
NM_013352 SART2 Squamous cell carcinoma antigen 0.22 0.31
NM_004362 CLGN Calmegin 0.21 0.19
AI912583 GLIPR1 GLI pathogenesis-related 1 (glioma) 0.21 0.45
Z19574 KRT17 Keratin 17 0.19 0.46
NM_003186 TAGLN1 Transgelin 0.19 0.14
NM_014059 RGC32 Response gene to complement 32 0.17 0.44
BE872674 CLEC3A C-type lectin domain family 3, member A 0.15 0.24
NM_003212 TDGF1/3 Teratocarcinoma-derived growth factor 1/3 0.13 0.47
BC000069 RARRES2 Retinoic acid receptor responder 2 0.07 0.33
AF110400 FGF19 Fibroblast growth factor 19 0.06 0.26
NM_006851 GLIPR1 GLI pathogenesis-related 1 0.05 0.28
NM_006169 NNMT Nicotinamide N-methyltransferase 0.04 0.24
AF208043 IFI16 Interferon, gamma-inducible protein 16 0.03 0.38
BG256677 IFI16 Interferon, gamma-inducible protein 16 0.02 0.40
NM_006169 NNMT Nicotinamide N-methyltransferase 0.02 0.24

Genes differentially expressed by at least twofold with a P-value < 0.05 including multiple testing correction were compared between HT29 and Caco-2 cells using Venn diagrams in GeneSpring GX software v 7.3.1. The table includes the GenBank IDs for all genes, their respective common names and the associated description. The ratio column corresponds to the fold change in expression of each gene relative to its sensitive counterpart.