Table 2.

MRI Annualized Percent Change Measures by Treatment Group

	Placebo total	Placebo APOE ∈4+	Placebo APOE ∈4−	Vit E total	Vit E APOE ∈4+	Vit E APOE ∈4−	Donepezil total	Donepezil APOE ∈4+	Donepezil APOE ∈4−
Hippocampus	−5.44 (3.20) [−16.40,−1.79]	−6.14 (3.49) [−16.40,−1.79]	−4.04 (1.94) [−9.12, −1.97]	−4.86 (2.50) [−11.83, −1.90]	−5.08 (2.59) [−11.83, −2.10]	−4.86 (2.50) [−10.94, −1.90]	−4.60 (2.18) [−10.71, −1.26]	−4.50 (2.28) [−10.71, −1.51]	−4.78 (2.07) [−7.54, −1.26]
ERC	−11.58 (9.27) [−44.99, 5.11]	−12.84 (9.36) [−44.99, 5.11]	−9.06 (8.80) [−44.43, −3.62]	−10.90 (5.84) [−27.17, −4.23]	−11.17 (6.16) [−26.78, −4.74]	−10.90 (5.84) [−27.17, −4.23]	−10.13 (5.63) [−29.59, −3.84]	−10.07 (5.11) [−23.80, −3.84]	−10.24 (6.68) [−29.59, −4.27]
Whole brain	−0.64 (0.80) [−2.85, 1.85]	−0.83 (0.94) [−2.85, 1.85]	−0.31 (0.32) [−1.06, 0.11]	−0.46 (0.54) [−2.02, 0.70]	−0.53(0.63) [−2.02, 0.70]	−0.46(0.54) [−0.72, 0.21]	−0.50 (0.52) [−1.97, 0.33]	−0.55(0.49) [−1.97, 0.21]	−0.41(0.59) [−1.73, 0.33]
Ventricle	4.54 (3.00) [0.75, 14.68]	5.48 (3.17) [1.77, 14.68]	2.89 (1.77) [0.75, 5.97]	3.99 (2.45) [−1.14, 9.68]	4.08 (2.56) [−1.14, 8.95]	3.99(2.45) [1.73, 9.68]	3.77 (2.36) [−0.53, 8.89]	4.18(2.01) [1.59, 8.89]	2.88(2.91) [−0.53, 8.79]

Mean (standard deviation) [minimum, maximum] Annualized Percent Change

APC values for the hippocampus, ERC, and brain are negative reflecting brain shrinkage, while values for the ventricle are positive reflecting ex vacuo ventricular expansion.