TABLE 3.
Associations of rs2166706 with secondary phenotypes among Indian Asians in the Hap300 sample and European Caucasians
| Indian Asians | P | European Caucasians | P | Phetero | |
|---|---|---|---|---|---|
| Type 2 diabetes† | 1.21 (1.06–1.38) | 0.006 | — | — | — |
| A1C (%)* | 0.12 (0.04–0.19) | 0.003 | — | — | — |
| HOMA-B* | −7.1 (−11.0 to −3.0) | 0.001 | −1.9 (−3.6 to −0.2) | 0.03 | 0.02 |
| HOMA-S* | 5.4 (−4.5 to 16.2) | 0.29 | 3.5 (−0.7 to 7.9) | 0.10 | 0.74 |
| BMI (kg/m2)* | −0.17 (−0.40 to 0.06) | 0.14 | −0.36 (−0.80 to 0.08) | 0.11 | 0.45 |
| Waist-to-hip ratio* | −0.001 (−0.005 to 0.003) | 0.64 | −0.005 (−0.013 to 0.002) | 0.16 | 0.36 |
| Hypertension† | 0.93 (0.82–1.05) | 0.22 | 1.00 (0.95–1.06) | 0.72 | 0.28 |
| Systolic blood pressure (mmHg)* | −0.9 (−1.9 to 0.12) | 0.08 | −0.2 (−1.6 to 1.2) | 0.79 | 0.43 |
| Diastolic blood pressure (mmHg)* | −0.6 (−1.3 to 0.0) | 0.05 | 0.0 (−1.2 to 1.2) | 0.99 | 0.39 |
| Cholesterol (mmol/l)* | 0.00 (−0.05 to 0.06) | 0.88 | 0.02 (−0.09 to 0.13) | 0.69 | 0.75 |
| HDL cholesterol (mmol/l)* | −0.2 (−1.5 to 1.1) | 0.78 | 1.4 (−1.1 to 3.9) | 0.28 | 0.27 |
| Triglycerides (mmol/l)* | 5.1 (−1.0 to 11.7) | 0.10 | −2.1 (−7.0 to 3.1) | 0.43 | 0.08 |
Effects are *unit change (initial to final quantity) or †odds ratio (95% CI) per allele copy, under additive genetic model, adjusted for sex (and age among Indian Asians).