Table 1.
Baseline patient characteristics and comorbidities of patients with trauma-related and nontrauma-related acute lung injury
| Characteristic | Trauma (n = 141) | Nontrauma (n = 1307) | p Value |
|---|---|---|---|
| Age, mean (sd), yrs | 44 (17) | 52 (17) | <.001 |
| Female gender, no. (%) | 89 (63) | 750 (57) | .18 |
| Race-ethnicity, no. (%)a | .036 | ||
| White | 118 (84) | 955 (73) | |
| Black | 10 (7) | 222 (17) | |
| Latino | 7 (5) | 79 (6) | |
| Asian | 3 (2) | 41 (3) | |
| AIDS, no. (%) | 1 (0.7) | 83 (6.4) | .003 |
| Leukemia, no. (%) | 0 (0) | 27 (2.1) | .10 |
| Lymphoma, no. (%) | 0 (0) | 16 (1.2) | .39 |
| Solid tumor with metastases, no. (%) | 0 (0) | 24 (1.8) | .16 |
| Immunosuppression within past 6 mos, no. (%)b | 2 (1.5) | 180 (13.8) | <.001 |
| Liver failure plus coma or encephalopathy, no. (%) | 1 (0.7) | 12 (0.9) | 1.0 |
| Cirrhosis, no. (%) | 2 (1.5) | 43 (3.3) | .31 |
| Diabetes, no. (%) | 5 (3.7) | 204 (15.7) | <.001 |
| Chronic dialysis, no. (%) | 0 (0) | 38 (2.9) | .044 |
| Enrolled in the low tidal volume trial | 96 | 806 | — |
| Low tidal volume arm of ARMA, no. (%) | 59 (61) | 414 (51) | .06 |
| Enrolled in ALVEOLI | 45 | 504 | — |
| Low PEEP arm of ALVEOLI, no. (%) | 26 (58) | 247 (49) | .26 |
| APACHE III score, mean (sd) | 67 (25) | 89 (30) | <.001 |
AIDS, acquired immunodeficiency syndrome; ALVEOLI, Assessment of Low Tidal Volume and Increased End-Expiratory Volume to Obviate Lung Injury; PEEP, positive end-expiratory pressure; APACHE, Acute Physiology, Age, and Chronic Health Evaluation.
a
Total may not equal 100% because of additional categories with very small numbers of patients
b
immunosuppression defined as radiation, chemotherapy, or prednisone at doses ≥0.3 mg/kg per day. Comparisons by Student's t-test, chi-square, or Fisher's exact test.