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. 2009 Sep 28;206(10):2191–2204. doi: 10.1084/jem.20091480

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© 2009 Tachdjian et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — The Q576R substitution promotes acute antigen-induced allergic airway inflammation. OVA-sensitized C.129.Il4ra^Q576/Q576 (Q576) and C.129.Il4ra^R576/R576 (R576) mice (n = 13 and 11, respectively) were challenged intranasally with OVA on three consecutive days and analyzed. (A) Lung histology (PAS staining). (B) Semiquantitative analysis of the severity of peribronchial inflammation represented by the mean of the inflammation scores, as described in Materials and methods. (C) Enumeration of PAS-positive goblet cells in the airways. (D) BAL fluid analysis for inflammatory cells. Values represent means ± SEM derived from two independent experiments. *, P < 0.05; **, P < 0.01. Bar, 200 µm.