Figure 2.
ATM Missense Substitutions Graded C65 by Align-GVGD and/or Scored 0.00 by SIFT
Substitution designations are given over their respective positions in the ATM alignment. Amino acid symbols are colored to represent standard Dayhoff groupings.
(A) Substitutions graded as C65; although most of these were scored 0.00 by SIFT, note that the last two fall at slightly variable positions and were scored as 0.01 by SIFT. “†” indicates that p.S2855R is the first substitution of the two-amino-acid substitution p.SV2855_2856RI.
(B) Substitutions scored as 0.00 by SIFT but as C55 or lower by Align-GVGD.