. Author manuscript; available in PMC: 2010 Jun 2.

Published in final edited form as: J Am Coll Cardiol. 2009 Jun 2;53(22):2061–2067. doi: 10.1016/j.jacc.2009.02.036

Table 3.

Odds Ratio (Unadjusted and Adjusted) for Coronary Artery Disease (CAD) Prevalence and Major Adverse Cardiac Events (MACE) at 3 Years with Increasing Quartiles of Citrulline and Ornithine Levels

	1^st quartile	2^nd quartile	3^rd quartile	4^th quartile
Citrulline (μM)	<15.3	15.3-21.2	21.3-29.4	>29.4

CAD Prevalence
Unadjusted OR (95% CI)	1.0	1.50 (1.05-2.15)^†	2.91 (2.01-4.20)^*	3.17 (2.18-4.61)^*
Adjusted OR (95% CI)	1.0	1.67 (1.14-2.46)^#	3.63 (2.40-5.51)^*	5.98 (3.72-9.60)^*

MACE at 3 years
Unadjusted HR (95% CI)	1.0	1.61 (0.87-2.97)	2.21 (1.2-3.96)^#	3.35 (1.93-5.82)^*
Adjusted HR (95% CI)	1.0	1.62 (0.87-3.01)	1.89 (1.05-3.1) ^†	2.40 (1.34-4.30)^#

Ornithine (μM)	<28.3	28.3-38.9	38.9-53.7	>53.8

CAD Prevalence
Unadjusted OR (95% CI)	1.0	1.30 (0.91-1.85)	1.67 (1.17-2.39)^#	2.29 (1.58-3.32)^*
Adjusted OR (95% CI)	1.0	1.35 (0.92-1.99)	2.32 (1.54-3.49)^*	3.95 (2.53-6.18)^*

MACE at 3 years
Unadjusted HR (95% CI)	1.0	1.12 (0.66-1.89)	1.44 (0.86-2.40)	1.54 (0.93-2.54)
Adjusted HR (95% CI)	1.0	1.06 (0.62-1.83)	1.16 (0.68-1.98)	1.23 (0.73-2.06)

p<0.001

p<0.01

^†

p<0.05