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. Author manuscript; available in PMC: 2009 Sep 23.
Published in final edited form as: Cell. 2008 Apr 18;133(2):292–302. doi: 10.1016/j.cell.2008.02.037

Figure 3. Interventions which decrease 60S ribosomal subunits extend RLS.

Figure 3

A. Relative to (i) wild-type, polysome profiles for (ii) nop12Δ, (iii) ssf1Δ, (iv) rei1Δ, and (v) diazaborine-treated (15 μg/ml) cells show significant reduction of 60S subunit levels while (vi) cycloheximide-treated (25 ng/ml) cells do not. B. Deletion of 60S-specific processing factor genes NOP12, SSF1, or LOC1 increases lifespan relative to experiment-matched wild-type cells. C. Treatment of wild-type cells with 15 μg/ml diazaborine extends lifespan relative to experiment-matched wild-type cells while treatment with 25 ng/ml cycloheximide does not. Mean lifespans are shown in parentheses.