FIG. 2.
Selective-advantage profiles of integrase mutants in the presence of increasing concentrations of raltegravir. Curves for single integrase mutants are presented on the upper panel, curves for dual integrase mutants are show on the lower panel. The selective index was calculated for each concentration of raltegravir as the ratio of mutant to wild-type NL4-3 infectivity, as measured using the same colorimetric method as in Fig. 1. The curves show the mean of at least three independent experiments with error bars representing the standard deviation.