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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Biol Psychiatry. 2009 Jun 11;66(5):494–502. doi: 10.1016/j.biopsych.2009.04.015

Figure 1. NPC proliferation is impaired in the dentate gyrus of GSK3 knockin mice.

Figure 1

Figure 1

Figure 1

(A) Immunoblots showing that serine phosphorylation of GSK3α and GSK3β is absent in the hippocampus of GSK3 knockin mice, whereas total and tyrosine-phosphorylated levels of GSK3α and GSK3β are equal in GSK3 knockin (KI) and wild-type (WT) mice. (B) Immunohistochemical detection of BrdU-positive cells (red) in the hippocampus of WT and KI mice. Nuclei are labeled with bisbenzimide (blue). Scale bar, 100 μm. (C) Unbiased stereological quantitation of BrdU-positive cells in the hippocampal dentate gyrus (DG). Values are means ± S.E.; n=10/group; *p<0.001. (D) Dentate gyrus volumes of WT and KI mice. Values are means ± S.E.; n=10/group. (E) Unbiased stereological quantitation of active caspase-3-positive cells in the hippocampal dentate gyrus WT and KI mice. Values are means ± S.E.; n=5/group.