Figure 8. Thio-S and Iron stained sections in AD mouse.
The same section was sequentially stained with Prussian Blue for iron (left) and Thio-S (right.) in a 24 month old transgenic mouse. Mean plaque size on Thio-S is fairly uniform through the brain, in particular no obvious difference in size is seen between plaques in the striatum vs. those in the cortex and hippocampus. In contrast, the iron content of striatal plaques is far greater than plaques in the cortex and hippocampus where Prussian blue staining is imperceptible.