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. Author manuscript; available in PMC: 2009 Sep 14.
Published in final edited form as: Nature. 2008 Nov 20;456(7220):350–356. doi: 10.1038/nature07413

Figure 2. DNA-binding features of the complex.

Figure 2

a, The sequence of PPRE element containing direct repeats of the canonical AGGTCA half-site separated by one base pair (DR1) together with the upstream sequence AAACT specificity element. b, The DBDs and their C-terminal extensions are shown for PPAR-γ (red) and RXR-α (blue). These domains form a polar, DNA-dependent head-to-tail interaction through side chains that converge over the spacer element.