FIGURE 6.
Model of functional Interplay between MAD2B and TCF4 in modulation of epithelial-mesenchymal transdifferentiation. TCF4-β-catenin complex binds the Slug promoter on TBS and transactivates Slug expression, which suppresses transcription of E-cadherin and induces EMT. Interaction of TCF4 with MAD2B inhibits the DNA binding ability of TCF4, which attenuates transactivation of Slug, thus releasing the suppression of E-cadherin and leading to mesenchymal-epithelial transdifferentiation (MET). β-CTN, β-catenin.