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Q331K and M337V accelerate spontaneous TDP-43 aggregation. A and B, TDP-43 or the indicated ALS-linked TDP-43 mutant (Q331K, M337V, or G294A) (3 μm) were incubated at 25 °C with agitation for 0–60 min. The extent of aggregation was determined by turbidity (A) or sedimentation analysis (B). Values represent means ± S.D. (n = 3). Inset (A) the equal input of TDP-43 proteins is shown on a Coomassie-stained gel.
