Table 3.
Association between GSTP1 and GST M1 genotype and newly diagnosed asthma.
| Models | Genotype and Haplotype† |
N (With asthma/ Without asthma) |
HR (95% CI)* | P-Value§ | |
|---|---|---|---|---|---|
| GSTP1 | Joint | SNP1(A) | 150/ | 1.23 (0.8–1.9) | 0.03 |
| SNP2(G) | 1474 | 0.85 (0.6–1.2) | |||
| SNP3(G) | 0.54 (0.3–0.9) ‖ | ||||
| SNP4(T) | 1.10 (0.6–1.9) | ||||
| Functional | SNP1(A) | 150/ | 1.40 (1.1–1.9) ‖ | 0.007 | |
| SNP3(G) | 1493 | 0.60 (0.4–0.8) ** | |||
| Haplotype‡ | TCAC | 150/ | 1 (Ref) | 0.14 | |
| ACAC | 1474 | 1.33 (0.8–2.2) | |||
| TGAC | 0.90 (0.6–1.4) | ||||
| TCGC | 0.64 (0.3–1.2) | ||||
| ACGT | 0.76 (0.5–1.2) | ||||
| Other | 0.97 (0.5–1.9) | ||||
| GSTM1 | Null | 152/ | 1.61 (1.2–2.2) ** | 0.004 | |
| 1472 | |||||
| Joint | GSTP1 | SNP1(A) | 144/ | 1.45 (1.1–1.9) ‖ | 0.007†† |
| GSTM1 | SNP3(G) | 1453 | 0.61 (0.4–0.8) ** | ||
| and GSTP1 | GSTM1 | Null | 1.52 (1.1–2.1) ‖ | ||
| Model |
Hazard ratio (HR) and 95% CI (95%CI) adjusted for community of residence and ethnicity. Additive genetic coding was used for all SNPs.
The letter within the parenthesis represents the variant allele.
The sequence of the GSTP1 haplotype is SNP1-SNP2-SNP3-SNP4. Haplotypes with less than 5% frequency in both the ethnic groups were summarized as ‘Other’.
The P-value is derived from likelihood ratio test (LRT). The LRT was calculated by comparing models with and without the corresponding genetic data.
p-value<0.05
p-value<0.001
This LRT P-value was calculated by comparing a model with SNP1 and SNP3 of GSTP1 and GSTM1 ‘null’, to one with only GSTM1 ‘null’. All models were adjusted for ethnicity and community of residence.