Table 1.
Effects of TAC on LV Structure and Function in WT vs. SPARC Null Mice
| Control | TAC | |||
|---|---|---|---|---|
| WT | SPARC Null | WT | SPARC Null | |
| Age (months) | 4 ± 1 | 4 ± 1 | 4 ± 1 | 4 ± 1 |
| BW (g) | 25 ± 1 | 24 ± 1 | 22 ± 1 | 23 ± 1 |
| Tibia Length (mm) | 20 ± 1 | 20 ± 1 | 20 ± 1 | 20 ± 1 |
| LV Mass (mg) | 85 ± 5 | 88 ± 4 | 126 ± 8* | 136 ± 9# |
| LV/BW (mg/g) | 3.5 ± 0.1 | 3.6 ± 0.1 | 5.7 ± 0.3* | 5.9 ± 0.3# |
| LV/TL (mg/mm) | 4.2 ± 0.2 | 4.4 ± 0.2 | 6.3 ± 0.4* | 6.8 ± 0.4# |
| AOPG (mmHg) | 0 | 0 | 97 ± 3* | 97 ± 3# |
| LV EDV (μL) | 36 ± 1 | 38 ± 2 | 40 ± 2 | 38 ± 1 |
| LV EF (%) | 70 ± 3 | 72 ± 1 | 67 ± 2 | 70 ± 1 |
| Wall Thickness (mm) | 0.7 ± 0.1 | 0.7 ± 0.1 | 1.0 ± 0.1* | 1.1 ± 0.1# |
| Heart Rate (bpm) | 440 ± 18 | 426 ± 11 | 411 ± 25 | 403 ± 14 |
Abbreviations: AOPG = Aortic pressure gradient across the transverse aortic constriction (TAC), BW = Body Weight, EDV = End Diastolic Volume, EF = Ejection Fraction, LV = Left Ventricular, SPARC = Secreted Protein Acidic and Rich in Cysteine, TL = Tibia Length, WT = Wild Type, Data are mean ± SEM
*
= p < 0.05 vs. Sham WT
#
= p < 0.05 vs. Sham SPARC Null, & = p <, 0.05 vs. WT TAC.