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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Annu Rev Biochem. 2009;78:363–397. doi: 10.1146/annurev.biochem.78.082307.091526

Figure 3.

Figure 3

Proteasome bound deubiquitinating enzymes. Deubiquitinating enzymes are indicated by red crescents, the substrate as a green line, and ubiquitin as blue ovals. POH1 catalyzes the release of a polyubiquitin chain “en bloc” as the substrate is engaged and translocated through the gated pore of the 20S protease. RPN10 (yellow) binds the polyubiquitin chain and the distal end of the chain can be removed by the action of UCH37 bound to ADRM1 (orange). USP14 is bound to the proteasome via interactions with RPN1 (purple) and probably removes mono ubiquitin attached to the substrate.