Figure 1.
Analysis of the wpk eye reveals a retinopathy. (A) TEM sections from wild-type (WT) and wpk animals show a failure to form the retinal outer segment (OS) at 3 weeks with a significant reduction in the outer nuclear layer (ONL). (B) By 50 days in the BN background, the ONL was almost completely absent. (C) TEM shows outer and inner segment (IS) formation in wild-type and wpk rats at 3 weeks. Although the OS does not form in the wpk, connecting cilia (arrows) are present. GC (ganglion cell), IPL (inner plexiform layer), INL (inner nuclear layer) and OPL (outer plexiform layer).