. Author manuscript; available in PMC: 2009 Aug 26.

Published in final edited form as: J Nucl Med. 2007 Sep 14;48(10):1724–1732. doi: 10.2967/jnumed.107.040279

TABLE 2.

Comparison of Data for Striatum and Cerebellum

Parameter	¹¹C-d-methamphetamine	¹¹C-l-methamphetamine
% dose/cm³ (peak)
Striatum	0.033 ± 0.008	0.036 ± 0.003
Cerebellum	0.034 ± 0.01	0.034 ± 0.004
Peak time (min)
Striatum	7.2 ± 2.3	7.5 ± 2.6
Cerebellum	4.5 ± 4.5	4.5 ± 1.5
Clearance half-time from peak (min)
Striatum	80.3 ± 18.6	98.5 ± 22.3
Cerebellum	59.3 ± 18.3	67.5 ± 12.3
DVR (Striatum:cerebellum)	1.22 ± 0.04	1.22 ± 0.027
Plasma integral for total ¹¹C at 60 min^*	2,411 ± 399 (1,348 ± 33)	1,833 ± 203 (1,351 ± 51)

There was a trend toward greater ¹¹C in plasma at 60 min for d-enantiomer (P < 0.08). Data in parentheses are fraction of ¹¹C as methamphetamine (mean ± SD, n = 3).