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. Author manuscript; available in PMC: 2009 Aug 4.
Published in final edited form as: Neurobiol Dis. 2007 Nov 4;29(3):422–437. doi: 10.1016/j.nbd.2007.10.005

Fig. 3.

Fig. 3

Effects of exogenous cholesterol on β- and γ-secretase activities in human brain tissue lysates. Panel A shows that 80 µM cholesterol (Cho) strongly stimulated β-secretase activity in ND brain lysates (One-way ANOVA, ***p<0.0001); while 40 µM and 80 µM cholesterol significantly enhanced β-secretase activity in AD brain lysates (One-way ANOVA, ***p<0.0001), respectively. Panel B shows that 80 µM cholesterol strongly stimulated γ-secretase activity in ND samples (One-way ANOVA, ***p<0.0001); while 40 µM cholesterol significantly stimulated γ-secretase activity in AD samples (One-way ANOVA, ***p<0.0001). Cholesterol at 20 µM concentration did not affect β-secretase activity, but inhibited γ-secretase activity in AD brain samples (***p<0.0001).