TABLE 2.
GLOBAL ASSOCIATION OF GSTM2 WITH FEV1 (ml) LEVEL AT AGE 18 AND 8-YEAR GROWTH USING HAPLOTYPE ANALYSIS: CHILDREN'S HEALTH STUDY, FOURTH GRADE COHORTS
| Haplotype* | β† | P Value | Global P Value‡ |
|---|---|---|---|
| Level at age 18 | 0.04 | ||
| 00101 | Ref | ||
| 10000 | 32.9 | 0.12 | |
| 00000 | −23.5 | 0.43 | |
| 10001 | 17.7 | 0.62 | |
| 01110 | 7.3 | 0.86 | |
| Other | 25.4 | 0.42 | |
| Growth | |||
| 10000 | 53.8 | 0.005 | |
| 00000 | 15.6 | 0.56 | |
| 10001 | 34.9 | 0.27 | |
| 01110 | 28.7 | 0.44 | |
| Other | 49.1 | 0.08 |
*
Haplotypes were defined by the following SNPs, in order: RS2073483, RS574344, RS655315, RS619686, and RS12024479, where “1” is the variant and “0” the common variant allele.
†
Difference in FEV1 comparing each haplotype to reference haplotype. All models adjusted for covariates listed in the Methods section.
‡
Global P value from likelihood ratio test of all haplotypes for growth and level at age 18 combined for the locus.