Table 3.
Transition rate parameters
| Parameter | Value | Reference |
|---|---|---|
| kIU | 6 × 10−7 ms−1 | (42) |
| [CaM] | 0.2 mM (≈ 20/dyad) | (52,68) |
| kIB | 10−5 nM−1 ms−1 | (26) |
| kBI | 8 × 10−4 ms−1 | (26) |
| kBToP | 8 × 10−4 ms−1 | Correspondence with authors of (26) |
| kT | 1.3 | Correspondence with authors of (26) |
| kPT | 10−3 ms−1 | (26) |
| kTP | 10−3μM−4 ms−1 | (26) |
| kTA | 8 × 10−7 ms−1 | (26) |
| kAT | 10−5 nM−1 ms−1 | (26) |
| kAC | 1.46 × 10−4 ms−1 | (43) |
| VmaxPP1 | 1.561 × 10−2units substrate × (units PP1)−1 ms−1 | New England Biolabs |
| [PP1] | 5/12 units PP1 × (units CaMKII)−1 | (44,45); and see description of CaMKII-LCC module |
| VmaxPP2A | 1.199 × 10−3units substrate × (units PP2A)−1 ms−1 | Gentaur Europe |
| ɛ | 0.6 units PP2A × (units substrate)−1 | None (see description of CaMKII-LCC module and Supporting Material) |