Table 5.
Association of MRI variables with severity of neuropsychological impairment
| NP impairment subgroup means |
|||||||
|---|---|---|---|---|---|---|---|
| Controls |
No impairment (GIS 0–1)* |
Mild-to-moderate impairment (GIS 2–5) |
Severe impairment (GIS ≥ 6) |
Linear trend analysis |
|||
| MRI variable | M ± SD | M ± SD | M ± SD | M ± SD | Effect size (% var)† |
F | p |
| Ventricular CSF percent | 4.8 ± 0.9 | 5.6 ± 1.3 | 6.9 ± 1.9 | 5.7 ± 2.0 | 6.7 | 3.02 | .091 |
| Sulcal CSF percent | 5.1 ± 0.9 | 5.4 ± 1.2 | 6.8 ± 1.7 | 5.9 ± 1.3 | 8.7 | 4.02 | .052 |
| Gray matter percent | 40.5 ± 2.6 | 40.3 ± 3.3 | 37.7 ± 2.8 | 38.6 ± 3.4 | 9.4 | 4.03 | .052 |
| White matter percent | 46.2 ± 2.0 | 45.5 ± 3.0 | 45.6 ± 2.0 | 46.1 ± 2.6 | 0.0 | 0.0 | .98 |
| WMSH (% of white matter) | 5.3 ± 3.1 | 4.7 ± 2.3 | 3.8 ± 1.7 | 6.5 ± 4.9 | 0.8 | 0.30 | .58 |
| Caudate volume (pixels) | 306 ± 25.8 | 282 ± 40.1 | 282 ± 26.2 | 282 ± 25.0 | 8.7 | 3.71 | .062 |
*
GIS: Global Impairment Score.
†
Percent of variance of MRI variables accounted for by increasing severity of NP impairment.