Figure 4. Activation of canonical Wnt signaling in oligodendrocyte lineage cells inhibits oligodendrocyte differentiation.
a-h) In situ hybridization of sections of spinal cord (a-d), forebrain (e-g) or cerebellum (h) taken from WT, Catnlox(ex3); Olig1Cre mice at indicated ages using probes to Olig2, Olig1, Pdgfrα, Plp, and Mbp. i-j) In situ hybridization of spinal cord sections of from WT and β-catenin KO (Ctnnb1lox/lox; Olig1Cre) mice at age E12.75 using probes to Olig2 and Pdgfrα as indicated. Arrows indicate the in situ labeled cells. Scale bars in a-d, e-h and i-j:100 μm.
