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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Biochem Pharmacol. 2008 Sep 20;77(4):485–497. doi: 10.1016/j.bcp.2008.09.016

Figure 2. AHR, NF-κB, and SP-1/3 binding sites in AHRR regulatory regions.

Figure 2

The murine AHRR proximal promoter on chromosome 13 contains 4 AHREs (closed ovals), 2 overlapping and 1 additional GC boxes (open rectangles), and 1 NF-κB binding site which overlaps with one of the GC boxes (closed diamond). Each of these sites has been functionally implicated in regulating constitutive and AHR ligand-induced AHRR transcription. A highly homologous regulatory sequence is located on the 5′ end of the human AHRR gene on chromosome 5.