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. Author manuscript; available in PMC: 2010 Jan 29.
Published in final edited form as: Neuron. 2009 Jan 29;61(2):234–246. doi: 10.1016/j.neuron.2008.12.006

Figure 7.

Figure 7

Model for action of Pias3 in photoreceptor differentiation. “S” indicates SUMOylated proteins, while “X” indicates an unidentified SUMOylated factor present on the promoters of rod-specific genes. Pias3 in rods binds and SUMOylates Nr2e3 to repress expression of S-cone-specific genes and simultaneously activates expression of rod-specific genes via a SUMOylation-dependent mechanism. Since Pias3-dependent activation of rod-specific genes does not require SUMOylation of Nr2e3 (see Figure S2), Pias3 must SUMOylate other transcription factors on rod-specific promoters (shown here as X).