Table 2.
Description of T1DGC MHC Fine Mapping Workshop data following QC procedures
| T1DGC: 2007.11.MHC, data characteristics, family summary: post-modification | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Contributor | Families | Families [n (%)] with |
||||||||
| Parents |
Affected full siblings |
Affected half siblings | ||||||||
| 0 | 1 | 2 | 0 | 1 | 2 | 3 | 4+ | |||
| Asia-Pacific | 191 | 25 (13.1) | 52 (27.2) | 114 (59.7) | 179 (93.7) | 9 (4.7) | 1 (0.5) | 2 (1.0) | ||
| Europe | 475 | 48 (10.1) | 104 (21.9) | 323 (68.0) | 2 (0.4) | 8 (1.7) | 440 (92.6) | 22 (4.6) | 1 (0.2) | 2 (0.4) |
| North America | 334 | 34 (10.2) | 96 (28.7) | 204 (61.1) | 8 (2.4) | 311 (93.1) | 12 (3.6) | 3 (0.9) | ||
| UK | 114 | 5 (4.4) | 24 (21.1) | 85 (74.6) | 5 (4.4) | 105 (92.1) | 3 (2.6) | 1 (0.9) | ||
| BDA | 418 | 4 (1.0) | 56 (13.4) | 358 (85.6) | 2 (0.5) | 38 (9.1) | 376 (90.0) | 1 (0.2) | 1 (0.2) | |
| Danish | 147 | 14 (9.5) | 38 (25.9) | 95 (64.6) | 3 (2.0) | 130 (88.4) | 14 (9.5) | |||
| HBDI | 431 | 10 (2.3) | 421 (97.7) | 7 (1.6) | 377 (87.5) | 40 (9.3) | 6 (1.4) | 1 (0.2) | ||
| Joslin | 112 | 40 (35.7) | 22 (19.6) | 50 (44.6) | 9 (8.0) | 94 (83.9) | 6 (5.4) | 3 (2.7) | ||
| Sardinian | 78 | 2 (2.6) | 22 (28.2) | 54 (69.2) | 1 (1.3) | 6 (7.7) | 71 (91.0) | |||
| Total | 2300 | 172 (7.5) | 424 (18.4) | 1704 (74.1) | 5 (0.2) | 84 (3.7) | 2083 (90.6) | 107 (4.7) | 9 (0.4) | 12 (0.5) |
MHC, major histocompatibility complex; T1DGC, Type 1 Diabetes Genetics Consortium; BDA, British Diabetes Association; HBDI, Human Biological Data Interchange.