Figure 4. NAG-1 protein activates apoptosis in urethane-induced pulmonary tumors.
(A) Normal (N) and tumor (T) tissue from control and NAG-1Tg+/FVB mice were subjected to caspase 3/7 activity assay. RLU, relative luciferase units. (mean ± S.D. from three different mice, **, p<0.01). (B) TUNEL assay of control (left panel) and NAG-1Tg+/FVB (right panel) mice. Positive control is shown as an insert in left panel. Asterisks indicate pulmonary adenomas; arrows indicate positively brown stained cells. Magnification 400×, scale bar 50 µm.
