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. Author manuscript; available in PMC: 2009 Jun 15.
Published in final edited form as: Pharmacol Rev. 2008 Dec 12;60(4):470–512. doi: 10.1124/pr.108.000604

FIG. 7.

FIG. 7

Structure of native GLP-1, exenatide, liraglutide, sitagliptin, and vildagliptin. Green letters indicate changes introduced in derivatives or occur naturally in exendin-4 (and replicated in the synthetic version, exenatide). The N-terminal dipeptide “HA” of GLP-1 and liraglutide is the site of proteolytic cleavage of DPP4. A broken red arrow indicates absent DPP4 activity, and a dotted red arrow indicates reduced DPP4 activity.