Fig. 5.
Veratridine enhancement of mitochondrial ATP turnover and inhibition of FCCP-stimulated respiration (A) in the presence and (B) in the absence of oligomycin. Synaptosomes were incubated in the presence of 15mM glucose + 10mM pyruvate. Where indicated veratridine (Vt, 0-5μM), oligomycin (oligo, 4μg/ml) and FCCP (4μM) were added. Rates are expressed relative to basal respiration in medium containing glucose but no pyruvate. (C, D) Corresponding relative acidification rates in the medium.
