Table 3. Multivariate adjusted hazard ratiosa (with lower and upper limits of 95% confidence intervals) for measures of height, obesity, and diabetes prevalence and total, aggressive, and non-aggressive cases of prostate cancerb.
|
Incident prostate cancer, entire cohort (n=10 434)
c
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|
|
All cases (n=809)
|
Aggressive cases (n=278)
|
Non-aggressive cases (n=525)
|
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| HR | Lower | Upper | HR | Lower | Upper | HR | Lower | Upper | |
| Height | |||||||||
| Quintile 1 | 1.00 | 1.00 | 1.00 | ||||||
| Quintile 2 | 1.18 | 0.95 | 1.47 | 1.38 | 0.96 | 1.98 | 1.08 | 0.82 | 1.43 |
| Quintile 3 | 1.08 | 0.86 | 1.34 | 1.14 | 0.79 | 1.66 | 1.04 | 0.79 | 1.37 |
| Quintile 4 | 1.04 | 0.81 | 1.34 | 1.01 | 0.65 | 1.56 | 1.08 | 0.79 | 1.46 |
| Quintile 5 | 1.31 | 1.05 | 1.64 | 1.29 | 0.87 | 1.91 | 1.33 | 1.01 | 1.76 |
| 0.081 | 0.64 | 0.055 | |||||||
| BMI | |||||||||
| Underweight | 2.29 | 1.13 | 4.63 | 3.15 | 1.15 | 8.62 | 0.84 | 0.63 | 1.11 |
| Normal | 1.00 | 1.00 | 1.00 | ||||||
| Overweight | 1.02 | 0.88 | 1.19 | 0.99 | 0.76 | 1.29 | 1.16 | 0.89 | 1.50 |
| Obese | 1.06 | 0.84 | 1.33 | 1.02 | 0.69 | 1.52 | 1.11 | 0.85 | 1.44 |
| Non-linear P | 0.15 d | 0.16 e | 0.65 f | ||||||
| BMI | |||||||||
| Quintile 1 | 1.00 | 1.00 | 1.00 | ||||||
| Quintile 2 | 0.94 | 0.76 | 1.17 | 0.83 | 0.57 | 1.20 | 1.01 | 0.76 | 1.33 |
| Quintile 3 | 0.96 | 0.77 | 1.20 | 0.89 | 0.62 | 1.29 | 0.99 | 0.75 | 1.31 |
| Quintile 4 | 0.99 | 0.80 | 1.24 | 0.89 | 0.61 | 1.28 | 1.06 | 0.81 | 1.40 |
| Quintile 5 | 0.90 | 0.72 | 1.13 | 0.83 | 0.57 | 1.22 | 0.94 | 0.71 | 1.26 |
| 0.58 | 0.49 | 0.86 | |||||||
| Body fat % | |||||||||
| Quintile 1 | 1.00 | 1.00 | 1.00 | ||||||
| Quintile 2 | 1.22 | 0.98 | 1.52 | 1.33 | 0.94 | 1.91 | 1.13 | 0.85 | 1.49 |
| Quintile 3 | 1.03 | 0.82 | 1.30 | 0.99 | 0.67 | 1.45 | 1.05 | 0.79 | 1.39 |
| Quintile 4 | 1.06 | 0.84 | 1.32 | 0.83 | 0.56 | 1.23 | 1.19 | 0.90 | 1.56 |
| Quintile 5 | 1.10 | 0.87 | 1.38 | 1.05 | 0.71 | 1.55 | 1.12 | 0.84 | 1.49 |
| 0.94 | 0.35 | 0.38 | |||||||
| Waist | |||||||||
| Quintile 1 | 1.00 | 1.00 | 1.00 | ||||||
| Quintile 2 | 0.90 | 0.71 | 1.13 | 0.80 | 0.55 | 1.18 | 0.94 | 0.70 | 1.25 |
| Quintile 3 | 1.05 | 0.84 | 1.30 | 0.93 | 0.64 | 1.34 | 1.10 | 0.83 | 1.44 |
| Quintile 4 | 1.04 | 0.83 | 1.29 | 0.89 | 0.61 | 1.30 | 1.12 | 0.84 | 1.47 |
| Quintile 5 | 1.00 | 0.80 | 1.26 | 0.99 | 0.68 | 1.45 | 1.00 | 0.75 | 1.34 |
| 0.55 | 0.84 | 0.58 | |||||||
| WHR | |||||||||
| Quintile 1 | 1.00 | 1.00 | 1.00 | ||||||
| Quintile 2 | 0.99 | 0.79 | 1.23 | 0.94 | 0.65 | 1.37 | 1.00 | 0.76 | 1.31 |
| Quintile 3 | 0.96 | 0.77 | 1.21 | 1.03 | 0.71 | 1.49 | 0.93 | 0.70 | 1.23 |
| Quintile 4 | 1.23 | 0.99 | 1.52 | 1.27 | 0.89 | 1.82 | 1.21 | 0.92 | 1.58 |
| Quintile 5 | 1.12 | 0.89 | 1.41 | 0.99 | 0.66 | 1.47 | 1.16 | 0.88 | 1.53 |
| 0.073 | 0.46 | 0.12 | |||||||
| Diabetes? | |||||||||
| No | 1.00 | 1.00 | 1.00 | ||||||
| Yes | 0.76 | 0.51 | 1.11 | 0.61 | 0.30 | 1.25 | 0.84 | 0.53 | 1.33 |
| 0.15 | 0.18 | 0.45 | |||||||
| Waist, adjusted for BMI | |||||||||
| Quintile 1 | 1.00 | 1.00 | 1.00 | ||||||
| Quintile 2 | 1.17 | 0.93 | 1.47 | 1.11 | 0.75 | 1.64 | 1.21 | 0.92 | 1.60 |
| Quintile 3 | 1.00 | 0.79 | 1.27 | 1.04 | 0.69 | 1.55 | 1.00 | 0.75 | 1.33 |
| Quintile 4 | 1.23 | 0.98 | 1.55 | 1.40 | 0.95 | 2.06 | 1.16 | 0.87 | 1.54 |
| Quintile 5 | 1.17 | 0.92 | 1.49 | 1.29 | 0.86 | 1.93 | 1.11 | 0.82 | 1.50 |
| 0.18 | 0.11 | 0.67 | |||||||
| WHR, adjusted for BMI | |||||||||
| Quintile 1 | 1.00 | 1.00 | 1.00 | ||||||
| Quintile 2 | 0.89 | 0.71 | 1.11 | 0.96 | 0.65 | 1.40 | 0.84 | 0.63 | 1.11 |
| Quintile 3 | 1.22 | 0.99 | 1.51 | 1.34 | 0.94 | 1.93 | 1.16 | 0.89 | 1.50 |
| Quintile 4 | 1.14 | 0.92 | 1.42 | 1.21 | 0.83 | 1.75 | 1.11 | 0.85 | 1.44 |
| Quintile 5 | 1.22 | 0.98 | 1.52 | 1.27 | 0.87 | 1.86 | 1.17 | 0.89 | 1.53 |
| 0.012 | 0.10 | 0.072 | |||||||
BMI=body mass index; WHR=waist–hip ratio; HR=hazard ratios.
P-values are in italics.
Adjusted for age, height, co-habitation status, socioeconomic status, alcohol habits, smoking habits, prevalent diabetes, total physical activity, birth country, and total intake of EPA, DHA, red meat, and calcium. Height and prevalent diabetes were further adjusted for BMI category.
All P-values are for linear trends (categorical variables), except where noted.
Some persons excluded from the analyses because of missing values, which also affect the number of cases.
Linear P=0.95.
Linear P=0.72.
Linear P=0.95.