Table 2. Genotype-sex interaction effects of the Reelin SNP rs75341475 (G→A) on schizophrenia.
Pinteraction for all samples combined = 1.6 × 10−5 (from ref.71).
| Sample | Sample Size (Cases/Controls) | Freq. GG (Cases/Controls | OR* (95% CI) GG Relative to GA+AA |
|---|---|---|---|
| Men | |||
| Ashkenazi | 470/1988 | 0.606/0.619 | 0.95 (0.77,1.17) |
| U.K. | 320/1439 | 0.709/0.725 | 0.93 (0.71, 1.21) |
| U.S. | 295/202 | 0.692/0.698 | 0.97 (0.66, 1.43) |
| Irish | 669/337 | 0.750/0.733 | 1.10 (0.81, 1.48) |
| Chinese | 222/229 | 0.806/0.830 | 0.85 (0.53, 1.38) |
| Combined | 1976/4195 | -- | 0.96 (0.85, 1.10) |
| Women | |||
| Ashkenazi | 265/656 | 0.755/0.610 | 1.97 (1.43, 2.71) |
| U.K. | 155/1488 | 0.813/0.702 | 1.85 (1.22, 2.81) |
| U.S. | 109/232 | 0.725/0.638 | 1.50 (0.91, 2.46) |
| Irish | 311/245 | 0.762/0.731 | 1.18 (0.80, 1.73) |
| Chinese | 193/229 | 0.845/0.825 | 1.15 (0.69, 1.93) |
| Combined | 1033/2850 | -- | 1.58 (1.31−1.89) |