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Activation of p38 MAPK contributes to the IL-1β-mediated behavioral decrease in mechanical threshold and thermal responsiveness. A, Phosphorylation of p38 in peripherin-positive cutaneous sensory fibers after intraplantar IL-1β injection (1 ng). B, Pretreatment with the p38 inhibitor SB203580 (50 μg) attenuated the effects of IL-1β on mechanical threshold and noxious heat response latency (mean ± SEM); *p < 0.05.
