Table 1.
Neurotransmitter genes upregulated in MSC-derived neurons.
| Neurotransmitter | Endogenous Source | Physiological Function | Reference |
|---|---|---|---|
| Acetycholine | Central/peripheral nervous system | Excitatory, skeletal muscle contraction, synaptic plasticity | (10, 21) |
| GABA | Central nervous system | Inhibitory or excitatory, brain development | (10, 22) |
| Neuropeptides | Central/peripheral nervous system | Synaptogenesis, glial morphology, tumorigenesis | (10, 23>) |
Classes of neurotransmitter genes that have been shown to be upregulated in MSC-derived neurons through a microarray approach (10). Except for the neuropeptide, SP, validation at the protein level was not previously studied.