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Varenicline (0.1 mg/kg) has no effect on contextual fear conditioning if administered only at training or testing (Figure 2A). Deficits in contextual fear conditioning produced by withdrawal of chronic nicotine administration are ameliorated by varenicline at training (Figure 2B). Significant difference (p < 0.05) from saline treated groups denoted with (*), significant difference (p < 0.05) from nicotine withdrawal groups denoted by (#).
