TABLE 5.
Dexamethasone- and SB706504-responsive inflammatory mediator probe sets in COPD MDMs whereby LPS has no effect or suppresses expression
|
Name
|
Affymetrix Identification
|
Description
|
Fold Change
|
|||
|---|---|---|---|---|---|---|
| LPSa | Dexamethasoneb | SB706504b | Dexamethasone and SB706504b | |||
| IL1RN | 216243_s_at | Interleukin 1 receptor antagonist | N.S. | -5.95 | -3.13 | -8.07 |
| TNFSF10 | 202687_s_at | TNF (ligand) superfamily, member 10 | N.S. | -3.99 | -2.62 | -9.52 |
| CXCL11 | 211122_s_at | Chemokine (C-X-C motif) ligand 11 | N.S. | -3.76 | N.S. | -11.95 |
| CSF1 | 211839_s_at | Colony-stimulating factor 1 (macrophage) | N.S. | -4.22 | N.S. | -4.16 |
| TNFSF7 | 206508_at | TNF (ligand) superfamily, member 7 | N.S. | -2.04 | N.S. | -3.13 |
| PBEF1 | 1555167_s_at | Pre-B-cell colony-enhancing factor 1 | N.S. | N.S. | -2.83 | -3.71 |
| PF4 | 206390_x_at | Platelet factor 4 [chemokine (C-X-C motif) ligand 4] | N.S. | N.S. | N.S. | 2.08 |
| LTB | 207339_s_at | Lymphotoxin β (TNF superfamily, member 3) | N.S. | N.S. | N.S. | -2.52 |
| XCL2 | 214567_s_at | Chemokine (C motif) ligand 2 | N.S. | N.S. | N.S. | -3.75 |
| FASLG | 210865_at | Fas ligand (TNF superfamily, member 6) | N.S. | N.S. | N.S. | -2.93 |
| TNFSF12 | 205611_at | TNF (ligand) superfamily, member 12 | -2.72 | 2.45 | 3.09 | 2.39 |
| TNFSF14 | 207907_at | TNF (ligand) superfamily, member 14 | -5.00 | N.S. | 2.65 | N.S. |
p < 0.01 unless fold change stated as N.S.
a
Fold change is relative to unstimulated MDMs
b
Fold change is LPS-stimulated MDMs plus drug relative to LPS only-stimulated MDMs