Table 3.
nsSNPs outside the MHC which meet a point-wise significance level of p < 10-3 for the Cochran-Armitage test for trend
| Disease | SNP | Chromosome | Position (bp) | MAF | OR | χ 2 | p value | Gene |
|---|---|---|---|---|---|---|---|---|
| AS | ||||||||
| rs696698 | 1 | 74777462 | .04 | 1.84 | 11.13 | 8.5 × 10-4 | C1orf173 | |
| rs10494217 | 1 | 119181230 | .17 | 0.77 | 11.62 | 6.5 × 10-4 | TBX15 | |
| rs2294851 | 1 | 206966279 | .13 | 0.73 | 13.55 | 2.3 × 10-4 | HHAT | |
| rs8192556 | 2 | 182368504 | .01 | 0.45 | 12.24 | 4.7 × 10-4 | NEUROD1 | |
| rs16876657 | 5 | 78645930 | .02 | 3.10 | 13.05 | 3.0 × 10-4 | JMY | |
| rs27044 | 5 | 96144608 | .34 | 1.40 | 23.90 | 1.0 × 10-6 | ARTS-1 | |
| rs17482078 | 5 | 96144622 | .17 | 0.76 | 13.55 | 2.3 × 10-4 | ARTS-1 | |
| rs10050860 | 5 | 96147966 | .18 | 0.75 | 14.87 | 1.1 × 10-4 | ARTS-1 | |
| rs30187 | 5 | 96150086 | .40 | 1.33 | 21.82 | 3.0 × 10-6 | ARTS-1 | |
| rs2287987 | 5 | 96155291 | .18 | 0.75 | 14.31 | 1.6 × 10-4 | ARTS-1 | |
| rs2303138 | 5 | 96376466 | .10 | 1.58 | 19.41 | 1.1 × 10-5 | LNPEP | |
| rs11750814 | 5 | 137528564 | .16 | 0.77 | 10.99 | 9.1 × 10-4 | BRD8 | |
| rs11959820 | 5 | 149192703 | .02 | 0.49 | 12.41 | 4.3 × 10-4 | PPARGC1B | |
| rs907609 | 11 | 1813846 | .13 | 0.76 | 10.91 | 9.5 × 10-4 | SYT8 | |
| rs3740691 | 11 | 47144987 | .29 | 0.80 | 11.86 | 5.7 × 10-4 | ZNF289 | |
| rs11062385 | 12 | 297836 | .24 | 0.79 | 11.82 | 5.9 × 10-4 | JARID1A | |
| rs7302230 | 12 | 7179699 | .08 | 1.57 | 14.97 | 1.1 × 10-4 | CLSTN3 | |
| AITD | ||||||||
| rs10916769 | 1 | 20408244 | .17 | 0.76 | 12.10 | 5.0 × 10-4 | FLJ32784 | |
| rs6427384 | 1 | 154321955 | .18 | 1.43 | 18.97 | 1.3 × 10-5 | FCRL5 | |
| rs2012199 | 1 | 154322098 | .17 | 1.35 | 13.18 | 2.8 × 10-4 | FCRL5 | |
| rs6679793 | 1 | 154327170 | .22 | 1.33 | 14.69 | 1.3 × 10-4 | FCRL5 | |
| rs7522061 | 1 | 154481463 | .47 | 1.25 | 13.78 | 2.1 × 10-4 | FCRL3 | |
| rs1047911 | 2 | 74611433 | .15 | 1.34 | 11.24 | 8.0 × 10-4 | MRPL53 | |
| rs7578199 | 2 | 241912838 | .26 | 1.26 | 11.53 | 6.9 × 10-4 | HDLBP | |
| rs3748140 | 8 | 9036429 | .00 | 0.28 | 11.44 | 7.2 × 10-4 | PPP1R3B | |
| rs1048101 | 8 | 26683945 | .42 | 0.82 | 10.98 | 9.2 × 10-4 | ADRA1A | |
| rs7975069 | 12 | 132389146 | .30 | 0.80 | 12.06 | 5.2 × 10-4 | ZNF268 | |
| rs2271233 | 17 | 6644845 | .07 | 0.94 | 11.32 | 7.7 × 10-4 | TEKT1 | |
| rs2856966 | 18 | 897710 | .19 | 0.76 | 14.00 | 1.8 × 10-4 | ADCYAP1 | |
| rs7250822 | 19 | 2206311 | .04 | 1.97 | 13.83 | 2.0 × 10-4 | AMH | |
| rs2230018 | 23 | 44685331 | .14 | 1.41 | 11.55 | 6.8 × 10-4 | UTX | |
| BC | ||||||||
| rs4255378 | 1 | 151919300 | .48 | 1.25 | 14.70 | 1.3 × 10-4 | MUC1 | |
| rs2107732 | 7 | 44851218 | .10 | 1.40 | 10.96 | 9.3 × 10-4 | CCM2 | |
| rs4986790 | 9 | 117554856 | .07 | 1.54 | 11.46 | 7.1 × 10-4 | TLR4 | |
| rs2285374 | 11 | 118457383 | .38 | 0.82 | 12.25 | 4.7 × 10-4 | VPS11 | |
| rs7313899 | 12 | 54231386 | .03 | 2.10 | 13.02 | 3.1 × 10-4 | OR6C4 | |
| rs2879097 | 17 | 34143085 | .20 | 0.78 | 11.73 | 6.1 × 10-4 | MEL18 | |
| rs2822558 | 21 | 14593715 | .13 | 0.73 | 13.87 | 2.0 × 10-4 | ABCC13 | |
| rs2230018 | 23 | 44685331 | .14 | 1.40 | 12.14 | 4.9 × 10-4 | UTX | |
| MS | ||||||||
| rs17009792 | 2 | 74400978 | .02 | 0.44 | 14.41 | 1.5 × 10-4 | SLC4A5 | |
| rs1132200 | 3 | 120633526 | .15 | 0.73 | 15.22 | 9.6 × 10-5 | FLJ10902 | |
| rs6897932 | 5 | 35910332 | .23 | 0.80 | 11.04 | 8.9 × 10-4 | IL7R | |
| rs6470147 | 8 | 124517985 | .36 | 1.23 | 10.92 | 9.5 × 10-4 | FLJ10204 | |
| rs3818511 | 10 | 134309378 | .24 | 1.28 | 12.84 | 3.4 × 10-4 | INPP5A | |
| rs11574422 | 11 | 67970565 | .02 | 2.82 | 14.64 | 1.3 × 10-4 | LRP5 | |
| rs388706 | 19 | 49110533 | .48 | 1.22 | 11.19 | 8.2 × 10-4 | ZNF45 | |
| rs1800437 | 19 | 50873232 | .17 | 0.74 | 16.11 | 6.0 × 10-5 | GIPR | |
| rs2281868 | 23 | 69451484 | .50 | 1.26 | 11.38 | 7.4 × 10-4 | SAP102 |