Fig. 1. Schematic representation of the human and Drosophila IAP family of proteins.
The number of residues in each IAP is shown, as well as the functional motifs that they contain. The BIRC nomenclature equivalents are provided. ILP2, ML-IAP, and Deterin are shown in this figure but not discussed in the review because little information about their function is available. NCBI GenBank (http://www.ncbi.nlm.nih.gov/Genbank) accession numbers are survivin: O15392; ILP2 : Q96P09; ML-IAP : Q96CA5; XIAP : P98710; c-IAP1 : Q13490; c-IAP2 : Q13489; NAIP : Q13075; Bruce : Q9NR09; Deterin : NM_142351; DIAP1 : Q24306; DIAP2 : Q24307: DBruce : NP_649995. CARD, caspase-associated recruitment domain; UBC, ubiquitin-conjugation; NOD, nucleotide-binding oligomerization domain; LRR, leucine-rich repeats.
