Figure 2. Kaplan–Meier Estimates of the Probability of Detection of Herpes Simplex Virus Type 2 (HSV-2) Infection at 24 Months.
During the 24-month study period in the intention-to-treat population, HSV-2 infection was detected in 114 subjects who had undergone circumcision (intervention group) and in 153 subjects who had not undergone the procedure (control group). The cumulative probability of HSV-2 infection during the 24-month period was 7.8% in the intervention group, as compared with 10.3% in the control group, with an unadjusted hazard ratio of 0.75 (95% CI, 0.60 to 0.94; P = 0.02). HSV-2 infection was initially detected at 6 months in 24 subjects in the intervention group and 35 in the control group and at 12 months in 29 subjects in the intervention group and 40 in the control group. At 24 months, HSV-2 infection was initially diagnosed in 61 subjects in the intervention group and 78 in the control group.
