FIGURE 7.
Involvement of CaMKII in Aβ reduction of AMPAR currents. A, immunocytochemical staining of CaMKII (red) in cultured cortical neurons transfected with CaMKII siRNA (co-transfected with GFP) or GFP alone. Arrowheads point to GFP+ neurons. B and C, representative traces of whole-cell AMPAR and NMDAR currents in cortical neurons transfected with CaMKII siRNA (B) or wild-type CaMKII (C) without or with Aβ treatment (1 μm, 3 days). Scale bar, 0.2 nA, 1 s. D, cumulative data (mean ± S.E.) showing the density of AMPAR or NMDAR currents in neurons transfected with GFP, CaMKII siRNA, or wild-type CaMKII without or with Aβ treatment.