Figure 2.
Brain anatomy and spine morphology in Rap2V12 transgenic mice. A, Coronal sections from 2-month-old Rap2V12, Rap2N17, and wild-type littermate mice stained with cresyl violet. Scale bar, 1 mm. B, Spine morphology of CA1 hippocampal neuron apical dendrites in Rap2V12, Rap2N17, and wild-type littermate mice (age, 2 months), visualized by DiI staining. Scale bar, 5 μm. C, Quantification of CA1 spine length, width, and density in Rap2V12 and Rap2N17 transgenic mice versus wild-type littermates. Error bars indicate SEM. *p < 0.05, unpaired t test.