. 2009 Jan 6;11(1):13–22. doi: 10.1208/s12248-008-9071-2

Table II.

Applications of Membrane-Disruptive Peptides for the Delivery of Various Therapeutic Macromolecules

AR-CPP	Membrane-disruptive peptide	Linkage between the AR-CPP and the membrane-disruptive peptide	Cargo delivered	Application in vitro	Application in vivo	Reference
TAT	HA2-TAT	Coincubation	Cre recombinase protein	Yes	No	(18)
TAT, Pen, Tp	Penetratin-HA2	Coincubation	PNA	Yes	No	(62)
Pen	Penetratin-HA2	Coincubation	siRNA	Yes	No	(63)
TAT	Modified HA2-TAT	Coincubation	Shepherdin peptide	Yes	No	(67)
TAT	Modified HA2-TAT	Coincubation	PM10 peptide	Yes	No	(68)
R11	Modified HA2-TAT	Fusion protein	P53 protein	Yes	No	(69)
4₆	4₃E	Ternary complex	Plasmid DNA	Yes	No	(70)
TAT	Histidine 10	Fusion protein	Plasmid DNA	Yes	Yes	(71)

Pen penetratin, Tp transportan, PNA peptide nucleic acid, R11 undecaarginine