Figure 6.
Induction of GluR2 phosphorylation at Ser880 (GluR2-p Ser880) and GluR2 internalization in cultured dorsal horn neurons after NMDAR and PKC activation. PMA stimulation increased expression of GluR2-p Ser880 (but not total GluR2) (A) and reduced surface expression of GluR2 (but not NR2B) (B); these changes were abolished by chelerythrine chloride (Chy). NMDA stimulation increased expression of GluR2-p Ser880 (but not total GluR2) (C) and reduced surface expression of GluR2 (but not NR2B) (D); these changes were abolished by both APV and Chy. **p < 0.01 versus control group.